Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers.

@article{Lacombe2013IdentificationAV,
  title={Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers.},
  author={J{\'e}r{\^o}me Lacombe and Alain Mang{\'e} and Marta Jarlier and C. Bascoul-Mollevi and P Rouanet and P J Lamy and Thierry Maudelonde and J{\'e}r{\^o}me Solassol},
  journal={International journal of cancer},
  year={2013},
  volume={132 5},
  pages={1105-13}
}
Evidence of circulating autoantibodies in cancer patient sera has created opportunities for exploiting them as biomarkers. We report the identification and the clinical validation of an autoantibody panel in newly diagnosed patients with early-stage breast cancer. Proteomic approach and serological screening of a discovery set of sera (n = 80) were performed to identify tumor-associated antigens (TAAs). Autoantibody levels were then measured in an independent validation set (n = 182) against a… CONTINUE READING