Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

@article{Lee2011IdentificationAV,
  title={Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.},
  author={Sherry Lee and K. G. Paulson and Elizabeth P. Murchison and Olga K. Afanasiev and Can Alkan and John H. Leonard and David R. Byrd and Gregory J Hannon and Paul Nghiem},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2011},
  volume={52 3},
  pages={272-5}
}
BACKGROUND Merkel cell polyomavirus (MCPyV) is present in approximately 80% of human Merkel cell carcinomas (MCCs). A previous in silico prediction suggested MCPyV encodes a microRNA (miRNA) that may regulate cellular and viral genes. OBJECTIVES To determine the presence and prevalence of a putative MCPyV-encoded miRNA in human MCC tumors. STUDY DESIGN Over 30 million small RNAs from 7 cryopreserved MCC tumors and 1 perilesional sample were sequenced. 45 additional MCC tumors were examined… CONTINUE READING
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