Identification and utilization of a 1,3-propanediol oxidoreductase isoenzyme for production of 1,3-propanediol from glycerol in Klebsiella pneumoniae

@article{Seo2009IdentificationAU,
  title={Identification and utilization of a 1,3-propanediol oxidoreductase isoenzyme for production of 1,3-propanediol from glycerol in Klebsiella pneumoniae},
  author={J W Seo and Mi-young Seo and Baek-Rock Oh and Sun-Yeon Heo and J O Baek and Dina Rairakhwada and Lian Hua Luo and Won-kyung Hong and Chulho Kim},
  journal={Applied Microbiology and Biotechnology},
  year={2009},
  volume={85},
  pages={659-666}
}
In a previous study, we showed that 1,3-propanediol (1,3-PD) was still produced from glycerol by the Klebsiella pneumoniae mutant strain defective in 1,3-PD oxidoreductase (DhaT), although the production level was lower compared to the parent strain. As a potential candidate for another putative 1,3-PD oxidoreductase, we identified and characterized a homolog of Escherichia coli yqhD (88% homology in amino acid sequence), which encodes an alcohol dehydrogenase and is well known to replace the… CONTINUE READING

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