Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

@article{Sisodia1993IdentificationAT,
  title={Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.},
  author={Sangram S. Sisodia and Edward H. Koo and Paul Ned Hoffman and George Perry and Donald L. Price},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1993},
  volume={13 7},
  pages={
          3136-42
        }
}
Amyloid deposits are a characteristic feature of the senile plaques identified in the brains of aged primates, individuals with Down's syndrome, and cases of Alzheimer's disease. The beta-amyloid protein (A beta), the principal component of amyloid, is a 4 kDa peptide derived from larger amyloid precursor protein(s) (APP). Four mRNAs, generated by alternative splicing of pre-mRNA derived from a single gene, encode A beta-containing membrane glycoproteins termed APP-695, -714, -751, and -770… CONTINUE READING
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