Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1.

@article{Engelmann2001IdentificationAT,
  title={Identification and topology of variant sequences within individual repeat domains of the human epithelial tumor mucin MUC1.},
  author={Katja Engelmann and Stephan Ernst Baldus and Franz-Georg Hanisch},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 30},
  pages={27764-9}
}
This study shows for the first time that the tandemly repeated icosapeptide of human MUC1 underlies a genetic sequence polymorphism at three positions (underlined): PDTRPAPGSTAPPAHGVTSA. The concerted replacement DT-->ES (sequence variation 1) and the single replacements P-->Q (sequence variation 2), P-->A (sequence variation 3), and P-->T (sequence variation 4) were identified by sequencing of polymerase chain reaction products and studied by minisatellite variant repeat analysis for their… CONTINUE READING

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