Identification and synthesis of impurities formed during sertindole preparation


Sertindole (1), an atypical anti-psychotic drug is used for the treatment of schizophrenia. During the laboratory optimization and later during its bulk synthesis the formation of various impurities was observed. The impurities formed were monitored and their structures were tentatively assigned on the basis of their fragmentation patterns in LC-MS. Most of… (More)
DOI: 10.3762/bjoc.7.5


1 Figure or Table