Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors.

@article{Liu2002IdentificationAS,
  title={Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors.},
  author={Jingjing Liu and Jie Zhou and Stephen P. Daiger and Debora B Farber and John R. Heckenlively and Julie E Smith and Lori Sullivan and Jian Zuo and Ann H. Milam and Eric A. Pierce},
  journal={Investigative ophthalmology & visual science},
  year={2002},
  volume={43 1},
  pages={22-32}
}
PURPOSE Mutations in the RP1 gene account for 6% to 10% of autosomal dominant retinitis pigmentosa (adRP). Previous studies have shown that the RP1 gene is expressed specifically in photoreceptor cells. So far, little is known about the RP1 protein or how mutations in RP1 lead to photoreceptor cell death. The goal of this study was to identify the RP1 protein and investigate its location in photoreceptor cells. METHODS A combination of RT-PCR and rapid amplification of cDNA ends (RACE) was… CONTINUE READING
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