Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylis

  title={Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-$\alpha$-pyrrolidinopropiophenone, 4-bromo-$\alpha$-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylis},
  author={Agata Błażewicz and Elżbieta Bednarek and Magdalena Popławska and Natalia Olech and Jerzy Sitkowski and Lech Kozerski},
  journal={Forensic Toxicology},
PurposeSeven synthetic cathinone derivatives detected in samples seized in Poland from clandestine laboratories: N-propylcathinone, 2,4-dimethylmethcathinone (2,4-DMMC), 2,4-dimethylethcathinone (2,4-DMEC), 2,4-dimethyl-α-pyrrolidinopropiophenone (2,4-DMPPP) and 2,4-dimethylisocathinone (4-iso-DMC), collected from smartshops: 4-bromo-α-pyrrolidinopropiophenone (4-Br-PPP) or received from an attorney 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one (5-BPDi) were identified and… 
4 Citations
Dehydration-fragmentation mechanism of cathinones and their metabolites in ESI-CID.
Findings presented herein indicate that the dehydrated ions in ESI-CID can be used for the structural identification of CATs, and provided evidence that CATs with tertiary amine structures do not undergo dehydration.
Metabolism of synthetic cathinones through the zebrafish water tank model: a promising tool for forensic toxicology laboratories
ZWT model indicated to be very useful to study the metabolism of the synthetic cathinones, such as N -ethylpentylone, ethyl one, α-PVP and 4-CDC, and seems to be a potent CYP450 inhibitor in zebrafish.
The Separation and Identification of Synthetic Cathinones by Portable Low Microflow Liquid Chromatography with Dual Capillary Columns in Series and Dual Wavelength Ultraviolet Detection.
This study ascertained the viability of a portable liquid chromatograph, operating at low μL/min flow, for the analysis of seized drugs at remote sites as well as in laboratory settings, and found this cost effective and green instrumentation has the potential to satisfy minimum international guidelines.


Identification and analytical characterization of nine synthetic cathinone derivatives N-ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α-EAPP, propylone, N-ethylnorpentylone, 6-MeO-bk-MDMA, α-PiHP, 4-Cl-α-PHP, and 4-F-α-PHP.
The mass-spectral fragmentations of these compounds following collision-induced dissociation (CID) and electron ionization (EI) were studied to assist forensic laboratories in identifying these compounds or other substances with similar structure in their case work.
Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC.
No chemical or pharmacological data about compounds 1-3 have appeared until now, making this the first report on these compounds, and the LC-MS and NMR data were added for additional characterization.
Spectroscopic characterization and crystal structures of two cathinone derivatives: 1-(4-chlorophenyl)-2-(1-pyrrolidinyl)-pentan-1-one (4-chloro-α-PVP) sulfate and 1-(4-methylphenyl)-2-(dimethylamino)-propan-1-one (4-MDMC) hydrochloride salts, seized on illicit drug market
Two compounds newly found in the seizures by drug enforcement agencies were identified and characterized by various instrumental analytical methods and X-ray crystallography was especially useful for identifying the salted forms and enantiomeric forms.
Spectroscopic and crystallographic characterization of two cathinone derivatives: 1-(4-fluorophenyl)-2-(methylamino)pentan-1-one (4-FPD) hydrochloride and 1-(4-methylphenyl)-2-(ethylamino)pentan-1-one (4-MEAP) hydrochloride
Analysis data useful in quick identification of the investigated compounds is presented, making it compulsory to obtain analytical data allowing unequivocal identification of these drugs in the fastest possible way.
Identification and structural characterization of four novel synthetic cathinones: α-methylaminohexanophenone (hexedrone, HEX), 4-bromoethcathinone (4-BEC), 4-chloro-α-pyrrolidinopropiophenone (4-Cl-PPP), and 4-bromo-α-pyrrolidinopentiophenone (4-Br-PVP) after their seizures
Over 560 new psychoactive substances have been detected via the European Union Early Warning System (EU-EWS) of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) between 2005 and
Analytical characterization of three cathinone derivatives, 4-MPD, 4F-PHP and bk-EPDP, purchased as bulk powder from online vendors.
Novel emerging drugs of abuse, also referred as new psychoactive substances, constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical
α-Pyrrolidinophenones: a new wave of designer cathinones
Pyrovalerone derivatives are associated with a growing number of reports of DUID (driving under the influence of drugs) and multidrug abuse, suggesting that they should be considered as posing a serious threat to public health.
The newest cathinone derivatives as designer drugs: an analytical and toxicological review
In this review, the new synthetic cathinones that have appeared on the illegal drug market during the period 2014–2017 are highlighted, and their characterization by gas chromatography–mass spectrometry and liquid chromatography-tandem mass spectromaetry is presented.
Formation of odd-electron product ions in collision-induced fragmentation of electrospray-generated protonated cathinone derivatives: aryl α-primary amino ketones.
  • E. Fornal
  • Chemistry
    Rapid communications in mass spectrometry : RCM
  • 2013
To help elucidate the correct structures of new aryl α-primary amino ketone drugs by LC/MS/MS, it is essential to include odd-electron product ions in the data interpretation rules.