Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.

@article{Tian2005IdentificationAS,
  title={Identification and structural characterisation of carboxy-terminal polypeptides and antibody epitopes of Alzheimer's amyloid precursor protein using high-resolution mass spectrometry.},
  author={Xiaodan Tian and Roxana Cecal and JoAnne McLaurin and Marilena Manea and Raluca Ștefănescu and Sandra Grau and Mona Harnasch and Sarah Amir and Michael Ehrmann and Peter St George-Hyslop and Markus Kohlmann and Michael Przybylski},
  journal={European journal of mass spectrometry},
  year={2005},
  volume={11 5},
  pages={547-56}
}
Alzheimer's disease (AD) is the most common cause for human age-related dementia, characterised by formation of diffuse plaques in brain that are directly involved in AD pathogenesis. The major component of AD plaques is beta-amyloid, a 40 to 42 amino acid polypeptide derived from the amyloid precursor protein (APP) by proteolytic degradation involving the specific proteases, beta-and gamma-secretase acting at the N- and C- terminal cleavage site, respectively. In this study we have prepared… CONTINUE READING