Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus.

@article{Huang1999IdentificationAS,
  title={Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus.},
  author={Yu Jing Huang and Roger K. Prichard},
  journal={Molecular and biochemical parasitology},
  year={1999},
  volume={102 2},
  pages={
          273-81
        }
}
The potential for the development of ivermectin (IVM) resistance in microfilariae of Onchocerca volvulus and the existence of IVM tolerance in adult worms of this human pathogen are major concerns for the effective control of onchocerciasis. P-glycoprotein (P-gp), an ATP-binding transporter protein associated with multidrug resistance in mammals, protozoa and the nematode, Haemonchus contortus, might play important roles in the development of IVM resistance and/or in the tolerance of adult O… CONTINUE READING
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