Identification and sequencing analysis of intact proteins via collision-induced dissociation and quadrupole time-of-flight mass spectrometry.

@article{NemethCawley2002IdentificationAS,
  title={Identification and sequencing analysis of intact proteins via collision-induced dissociation and quadrupole time-of-flight mass spectrometry.},
  author={Jennifer F Nemeth-Cawley and Jason C. Rouse},
  journal={Journal of mass spectrometry : JMS},
  year={2002},
  volume={37 3},
  pages={270-82}
}
Identifying unknown proteins has become a central focal point for proteomic and biopharmaceutical development laboratories. Our laboratory investigated using quadrupole time-of-flight mass spectrometry (Qq/TOFMS) for the analysis of intact proteins for the purpose of identifying unknowns while limiting the number of sample-handling steps between protein extraction and identification. Eight standard proteins, both unmodified and disulfide-bonded and ranging in mass from 5 to 66 kDa, were… CONTINUE READING

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