Identification and sequence of a fourth human T cell antigen receptor chain

@article{Loh1987IdentificationAS,
  title={Identification and sequence of a fourth human T cell antigen receptor chain},
  author={Elwyn Y. Loh and Lewis L. Lanier and Christoph Wilhelm Turck and Dan R. Littman and M. M. Davis and Yueh-hsiu Chien and Arthur Weiss},
  journal={Nature},
  year={1987},
  volume={330},
  pages={569-572}
}
Thymus-derived lymphocytes (T cells) use clonally distributed antigen receptors to recognize peptide fragments associated with products of the major histocompatibility complex (MHC) (refs 1–4). On most murine and human T cells the T cell receptor (TCR) is composed of disulphide-linked α and β chains (TCRα/β), each of which contains constant and variable domains, and which are associated with the invariant chains of the CD3 complex5,6. It has been demonstrated, however, that a distinct CD3… CONTINUE READING