Identification and resolution of artifacts in the interpretation of imprinted gene expression.

@article{Proudhon2010IdentificationAR,
  title={Identification and resolution of artifacts in the interpretation of imprinted gene expression.},
  author={Charlotte Proudhon and D{\'e}borah Bourc'his},
  journal={Briefings in functional genomics},
  year={2010},
  volume={9 5-6},
  pages={374-84}
}
Genomic imprinting refers to genes that are epigenetically programmed in the germline to express exclusively or preferentially one allele in a parent-of-origin manner. Expression-based genome-wide screening for the identification of imprinted genes has failed to uncover a significant number of new imprinted genes, probably because of the high tissue- and developmental-stage specificity of imprinted gene expression. A very large number of technical and biological artifacts can also lead to the… CONTINUE READING

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