Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.

Abstract

BACKGROUND The development of inhibitors in hemophiliacs is a severe complication of factor VIII (FVIII) replacement therapy and is a process driven by FVIII specific T helper cells. OBJECTIVES To finely map T cell epitopes within the whole FVIII protein in order to investigate the possibility of engineering FVIII variants with reduced propensity for… (More)

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Cite this paper

@article{Jones2005IdentificationAR, title={Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.}, author={Timothy Jones and W. J. Phillips and B. J. Smith and Christi Bamford and Prakash D Nayee and Terri Baglin and J S H Gaston and Maureen Baker}, journal={Journal of thrombosis and haemostasis : JTH}, year={2005}, volume={3 5}, pages={991-1000} }