Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.

@article{Jones2005IdentificationAR,
  title={Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.},
  author={Tim D. Jones and William J Phillips and Brent James Smith and Colleen Bamford and Prakash D Nayee and Trevor P Baglin and J S H Gaston and Matthew P. Baker},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2005},
  volume={3 5},
  pages={991-1000}
}
BACKGROUND The development of inhibitors in hemophiliacs is a severe complication of factor VIII (FVIII) replacement therapy and is a process driven by FVIII specific T helper cells. OBJECTIVES To finely map T cell epitopes within the whole FVIII protein in order to investigate the possibility of engineering FVIII variants with reduced propensity for inhibitor development. PATIENTS AND METHODS T cell lines were generated from five patients with severe hemophilia who had developed inhibitors… CONTINUE READING

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