Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.

@article{Merke1989IdentificationAR,
  title={Identification and regulation of 1,25-dihydroxyvitamin D3 receptor activity and biosynthesis of 1,25-dihydroxyvitamin D3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries.},
  author={J{\"u}rgen Merke and P. Milde and Sabina Lewicka and Ulrike Huegel and Guenter Klaus and David J Mangelsdorf and Mark R. Haussler and Ernst W. Rauterberg and Eberhard Ritz},
  journal={The Journal of clinical investigation},
  year={1989},
  volume={83 6},
  pages={1903-15}
}
Because 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has been shown to play roles in both proliferation and differentiation of novel target cells, the potential expression of 1,25(OH)2D3 receptor (VDR) activity was investigated in cultured bovine aortic endothelial cells (BAEC). Receptor binding assays performed on nuclear extracts of BAEC revealed a single class of specific, high-affinity VDR that displayed a 4.5-fold increase in maximal ligand binding (Nmax) in rapidly proliferating BAEC compared… CONTINUE READING
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