Identification and quantitation of methotrexate and methotrexate metabolites in clinical high-dose therapy by high pressure liquid chromatography and field desorption mass spectrometry.

@article{Przybylski1982IdentificationAQ,
  title={Identification and quantitation of methotrexate and methotrexate metabolites in clinical high-dose therapy by high pressure liquid chromatography and field desorption mass spectrometry.},
  author={Michael J Przybylski and Jack Preiss and R Dennebaum and Jan Fischer},
  journal={Biomedical mass spectrometry},
  year={1982},
  volume={9 1},
  pages={22-32}
}
High-pressure liquid chromatography in combination with field desorption mass spectrometry as techniques of high specificity and sensitivity have been applied to the identification and quantitation of the anticancer drug methotrexate and its metabolites which occur in clinical high-dose therapy. Field desorption mass spectra of methotrexate and several methotrexate and folic acid derivatives, when investigated as free acids or ammonium salts, yield abundant protonated molecular ions and a… CONTINUE READING

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