Identification and quantification of synthetic cannabinoids in “spice-like” herbal mixtures: update of the German situation for the spring of 2015
@article{Langer2015IdentificationAQ, title={Identification and quantification of synthetic cannabinoids in “spice-like” herbal mixtures: update of the German situation for the spring of 2015}, author={Nico Langer and Rainer Lindigkeit and Hans Martin Schiebel and Uli Papke and Ludger Ernst and Till Beuerle}, journal={Forensic Toxicology}, year={2015}, volume={34}, pages={94-107} }
In February 2015, 13 “spice-like” products, available on the German market, were analyzed. In total, eight different synthetic cannabinoids were identified by gas chromatography–mass spectrometry (GC–MS), namely 5-fluoro-AB-PINACA, AB-CHMINACA, AB-FUBINACA, 5-fluoro-PB-22, 5-fluoro-AMB, MDMB-CHMICA, EAM-2201 and STS-135. In most of the products (11/13), only one synthetic cannabinoid was identified, while two products contained two or three synthetic cannabinoids. For some of the compounds (5…
34 Citations
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References
SHOWING 1-10 OF 30 REFERENCES
Analysis of synthetic cannabinoids in “spice-like” herbal highs: snapshot of the German market in summer 2011
- ChemistryAnalytical and Bioanalytical Chemistry
- 2012
Analysis of commercial “spice-like” products available on the German market were analyzed and a general method using an isotopically labeled internal standard (JWH-018-D3) to quantify synthetic cannabinoids in herbal mixtures was established.
Identification and quantification of synthetic cannabinoids in 'spice-like' herbal mixtures: a snapshot of the German situation in the autumn of 2012.
- ChemistryDrug testing and analysis
- 2014
Based on the purified compounds a universal gas chromatography-mass spectrometry (GC-MS) method was developed for the identification and quantification of these compounds in commercial smoking blends, finding up to five different compounds could be found in such products showing total concentrations from 72 to 303 mg/g smoking blend while individual compounds ranged from 0.4 to 0.8%.
A large amount of new designer drug diphenidine coexisting with a synthetic cannabinoid 5-fluoro-AB-PINACA found in a dubious herbal product
- ChemistryForensic Toxicology
- 2014
Traffic police brought five dubious herbal product packages to our laboratory for toxicological analysis. These products usually contain one or multiple kinds of synthetic cannabinoids. In one of the…
Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products
- ChemistryForensic Toxicology
- 2014
From November 2013 to May 2014, 19 newly distributed designer drugs were identified in 104 products in our ongoing survey of illegal products in Japan. The identified compounds included 8 synthetic…
Synthetic cannabinoids in "spice-like" herbal blends: first appearance of JWH-307 and recurrence of JWH-018 on the German market.
- ChemistryForensic science international
- 2012
A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products
- ChemistryForensic Toxicology
- 2015
Six new psychoactive substances were identified together with two other substances (compounds 1–8) in illegal products by our ongoing survey in Japan between January and July 2014. A new synthetic…
Structure elucidation and identification of a common metabolite for naphthoylindole-based synthetic cannabinoids using LC-TOF and comparison to a synthetic reference standard.
- ChemistryForensic science international
- 2013
URB-754: a new class of designer drug and 12 synthetic cannabinoids detected in illegal products.
- ChemistryForensic science international
- 2013
Effects of bioisosteric fluorine in synthetic cannabinoid designer drugs JWH-018, AM-2201, UR-144, XLR-11, PB-22, 5F-PB-22, APICA, and STS-135.
- Chemistry, BiologyACS chemical neuroscience
- 2015
In vitro functional activities of SC designer drugs JWH-018, UR-144, PB-22, and APICA, and their respective terminally fluorinated analogues and in vivo in vivo cannabinoid type 1 receptor binding affinity evaluated in rats showed no consistent trend for increased potency of fluorinated SCs over the corresponding des-fluoro SCs in vivo.