Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia

@inproceedings{Chouchani2017IdentificationAQ,
  title={Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia},
  author={Edward T. Chouchani and Andrew M. James and Carmen Methner and Victoria R. Pell and Tracy A. Prime and Brian K Erickson and Marleen Forkink and Gigi Y Lau and Thomas P. Bright and Katja E. Menger and Ian M. Fearnley and Thomas Krieg and Michael P Murphy},
  booktitle={The Journal of biological chemistry},
  year={2017}
}
Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure. NO2- may act by S-nitrosating protein thiols, thereby altering protein activity. But how this occurs, and the functional importance of S-nitrosation sites across the mammalian proteome, remain largely uncharacterized. Here we analyzed protein thiols… CONTINUE READING
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