Identification and quantification of aberrant crypt foci and microadenomas in the human colon.

@article{Roncucci1991IdentificationAQ,
  title={Identification and quantification of aberrant crypt foci and microadenomas in the human colon.},
  author={Luca Roncucci and Dennis H Stamp and Alan Medline and Jacquelyn B. H. Cullen and William Robert Bruce},
  journal={Human pathology},
  year={1991},
  volume={22 3},
  pages={
          287-94
        }
}
Classification of aberrant crypt foci and microadenomas in human colon.
  • L. Roncucci, A. Medline, W. R. Bruce
  • Medicine
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1991
TLDR
The presence of slit-like lumen in the crypts of ACF on the mucosal surface correlated with the presence of dysplasia at histology, thus identifying microadenomas, a putative precursor lesion of colon cancer.
Aberrant crypt foci in patients with colorectal cancer.
TLDR
Density of ACF correlates with colorectal cancer rates in two Italian provinces, and shows a positive gradient from proximal to distal large bowel, and suggests they may be precursors of both hyperplastic and adenomatous polyps.
Histology of aberrant crypt foci in the human colon
Aberrant crypt foci (ACF) have been identified in the methylene‐blue stained mucosa of the human colon. Some lines of evidence suggest that ACF may be precursors of colon cancer. The objective of the
Emergence of adenomatous aberrant crypt foci (ACF) from hyperplastic ACF with concomitant increase in cell proliferation.
TLDR
Observations suggest that some hyperplastic ACF may develop into adenomatous ACF by way of stage I abnormality ACF with concomitant acquisition of higher proliferative activity through some genetic and/or epigenetic changes.
Rectal aberrant crypt foci (ACF) as a predictor of benign and malignant neoplastic lesions in the large intestine
TLDR
Rectal ACF are a useful marker for the presence of cancerous lesions in the proximal and distal sections of the large intestine and can correlate with the number and specific types of polyps in the large intestinal.
Detection of aberrant crypt foci by magnifying colonoscopy.
Identification of Mucin Depleted Foci in the Human Colon
TLDR
The occurrence of MDF-like lesions in high-risk patients provides evidence that these lesions have a counterpart in human pathology and, as observed in rodents, may represent the very early stages of CRC.
Aberrant crypt foci as microscopic precursors of colorectal cancer.
TLDR
The technique of magnifying chromoscope makes it possible to detect "in vivo" ACF, which is beneficial to colon cancer research, identifying high-risk populations for CRC, and developing preventive procedures.
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