Identification and quantification of 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case

  title={Identification and quantification of 4′-methoxy-$\alpha$-pyrrolidinobutiophenone (4-MeOPBP) in human plasma and urine using LC–TOF-MS in an autopsy case},
  author={Kaori Shintani-ishida and Mami Nakamura and Misa Tojo and Nozomi Idota and Hiroshi Ikegaya},
  journal={Forensic Toxicology},
We encountered an autopsy case of a 35-year-old man who drowned in a bathtub. Nine opened packages of designer drugs containing herbal blends, powders, or liquid were found at the scene, implying abuse. The plasma and urine samples of the deceased were analyzed using liquid chromatography–time-of-flight-mass spectrometry (LC–TOF-MS) with MSE. A new synthetic cathinone, 4′-methoxy-α-pyrrolidinobutiophenone (4-MeOPBP), emerged as a suspected component via elemental composition and molecular… 

Successful quantification of 4′-methyl-α-pyrrolidinohexanophenone (MPHP) in human urine using LC–TOF-MS in an autopsy case

This study successfully quantified unmetabolized MPHP in urine of an autopsy case using a sensitive method by liquid chromatography–time-of-flight-mass spectrometry.

Rapid detection of tert-butoxycarbonyl-methamphetamine by direct analysis in real time time-of-flight mass spectrometry

DART–TOF-MS provides a rapid and accurate method for the detection of t-Boc-MP, allowing suppression of the pyrolysis reaction and identification of both fragment ions and protonated t- Boc- MP.

Application of high-resolution mass spectrometry to determination of baclofen in a case of fatal intoxication

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α-Pyrrolidinophenones: a new wave of designer cathinones

Pyrovalerone derivatives are associated with a growing number of reports of DUID (driving under the influence of drugs) and multidrug abuse, suggesting that they should be considered as posing a serious threat to public health.

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A comprehensive systematic review addressing in vitro and in vivo synthetic cathinone pharmacokinetics, analytical methods for detection and quantification in biological matrices, and toxicological findings from human performance and postmortem toxicology cases is presented.

Rapid Determination of Sufentanil in Human Plasma by UHPLC-QqQ-MS-MS.

This method is suitable not only for evaluation of the pharmacokinetics, toxicology, bioavailability, and clinical pharmacology of sufentanil, but also for the detection and identification of this compound in human plasma samples for forensic purposes.

Blood concentrations of synthetic cathinones

Where there is clinical suspicion of death due to synthetic cathinones, postmortem blood concentrations >1 μg/mL (in person without developed tolerance) can be cautiously considered as lethal concentrations, however the exact ranges cannot be established.



Postmortem distribution of α-pyrrolidinovalerophenone and its metabolite in body fluids and solid tissues in a fatal poisoning case measured by LC–MS–MS with the standard addition method

The extremely high concentration of the drug in urine and the relatively high concentration in the kidney suggested that α-PVP is rapidly excreted into urine via the kidney, and the findings of this study will be useful for assessment of future cases of α-pyrrolidinovalerophenone poisoning.

MALDI-TOF mass spectrometric determination of four pyrrolidino cathinones in human blood

A rapid and sensitive detection method using matrix-assisted laser desorption ionization (MALDI)–time-of-flight (TOF)–mass spectrometry (MS) was developed for the analysis of four pyrrolidino

Validation of LC-TOF-MS screening for drugs, metabolites, and collateral compounds in forensic toxicology specimens.

This method represents a rapid, enhanced screen for blood and urine specimens in postmortem, driving under the influence, and drug facilitated sexual assault forensic toxicology casework.

Time-course profile of urinary excretion of intravenously administered α-pyrrolidinovalerophenone and α-pyrrolidinobutiophenone in a human

The time-course profile of urinary excretion of α-pyrrolidinovalerophenone (α-PVP) and α-PBP after intravenous injection in a man aged in his forties who intravenously injected unknown amounts of so-called unregulated drugs with the intention to commit suicide is reported.

Confirmation of cocaine exposure by gas chromatography-mass spectrometry of urine extracts after methylation of benzoylecgonine.

  • M. YonamineO. A. Silva
  • Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2002

SPME–GC–MS analysis of α-pyrrolidinovaleorophenone in blood in a fatal poisoning case

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UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.

The composition of rat urine was studied using this new approach, allowing the structures of several endogenous components to be confirmed in one analytical run by the simultaneous acquisition of exact mass precursor and fragment ion data.

Recently abused synthetic cathinones, α-pyrrolidinophenone derivatives: a review of their pharmacology, acute toxicity, and metabolism

The aim of this review is to present the chemical aspects, pharmacology, acute toxicities, and metabolisms of α-pyrrolidinophenone derivatives, a new group of synthetic cathinones. Compared to other

A fatal case of 3,4-methylenedioxypyrovalerone poisoning: coexistence of α-pyrrolidinobutiophenone and α-pyrrolidinovalerophenone in blood and/or hair

This is the first report dealing with MDPV in human hair segments, and with α-PBP in human specimens, and it is concluded that the woman died of acute M DPV poisoning, and that she had abused MDPVs and α-pyrrolidinobutiophenone for a long time.