Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs

@article{Voeller2000IdentificationAP,
  title={Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs},
  author={Donna M. Voeller and Jean L Grem and Yves Pommier and Ken Paull and Carmen Joseph Allegra},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2000},
  volume={45},
  pages={409-416}
}
Purpose: To investigate the effects of several camptothecin analogs including 9-aminocamptothecin (9-AC), SN38, topotecan, and irinotecan (CPT-11) on the enzymes involved in the pyrimidine salvage pathway including thymidylate synthase (TS). A COMPARE analysis using the NCI 60 cell line drug-screening panel suggested that there were similarities in the mechanisms of action of camptothecin analogs and TS inhibitors. Methods: TS enzymatic activity was measured by both an in situ tritium release… CONTINUE READING

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