Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches.

@article{Svetlov2006IdentificationAP,
  title={Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches.},
  author={Stanislav I. Svetlov and Y. P. Xiang and Monika W Oli and David P. Foley and Guoxiang Huang and Ronal L Hayes and A. K. Ottens and Kevin K W Wang},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  year={2006},
  volume={11 4},
  pages={355-69}
}
Hepatic ischaemia/reperfusion (I/R), a major cause of liver damage associated with multiple trauma, haemorrhagic and septic shock, and liver transplantation, contributes significantly to multiple organ failure. Development of novel sensitive biomarkers that detect early stages of liver damage is vital for effective management and treatment of ischaemic liver injury. By using high-throughput immunoblotting and cation-anion exchange chromatography/reversed-phase liquid chromatography-tandem mass… CONTINUE READING
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