Identification and physicochemical characterization of caffeine-citric acid co-crystal polymorphs.

Abstract

The purpose of the present study was to identify a new caffeine-citric acid co-crystal (CA-CI) polymorph and characterize three CA-CI polymorphs. The stability order among the three CA-CI polymorphs was also determined. One new and two known CA-CI polymorphs were prepared by the liquid-assisted grinding method or the slurry methods. The three CA-CIs were… (More)
DOI: 10.1016/j.ejps.2015.09.002

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@article{Mukaida2015IdentificationAP, title={Identification and physicochemical characterization of caffeine-citric acid co-crystal polymorphs.}, author={Makoto Mukaida and Yuka Watanabe and Kiyohiko Sugano and K. Terada}, journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences}, year={2015}, volume={79}, pages={61-6} }