Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.

@article{Chen2005IdentificationAP,
  title={Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.},
  author={Jingcai Chen and Chester Kuei and Steven W. Sutton and Sandy Wilson and Jingxue Yu and Fredrik Kamme and C. Mazur and Timothy W. Lovenberg and Changlu Liu},
  journal={Molecular pharmacology},
  year={2005},
  volume={67 6},
  pages={2070-6}
}
Prokineticins 1 and 2 (PK1 and PK2) have been recently identified from humans and other mammals and play multiple functional roles. PK proteins are ligands for two G protein-coupled receptors, PK receptor 1 (PKR1) and PK receptor 2 (PKR2). Here, we report the molecular cloning and pharmacological characterization of an alternatively spliced product of the PK2 gene encoding 21 additional amino acids compared with PK2, designated PK2L (for PK2 long form). PK2L mRNA is broadly expressed, as is PK2… CONTINUE READING