Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein.

@article{Majumdar1994IdentificationAM,
  title={Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein.},
  author={Manas K. Majumdar and Li Nian Feng and Eugene S. Medlock and Deniz Toksoz and David A Williams},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 2},
  pages={1237-42}
}
Phenotypic abnormalities of melanocytes, germ cells, and hematopoietic cells of Steel mice demonstrate the critical role of stem cell factor (SCF) in development. Production of SCF in the hematopoietic microenvironment as either a membrane-associated or soluble factor leads to pleiotropic effects on hematopoietic stem and progenitor cells and significant effects on the production of erythroid cells. Although the production of these two forms of SCF is highly regulated, the physiologic role(s… CONTINUE READING

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