Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

  title={Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31},
  author={Jennifer Permuth-Wey and Kate Lawrenson and Howard C-H Shen and Aneliya Velkova and Jonathan P. Tyrer and Zhihua Chen and Hui-Yi Lin and Y. Ann Chen and Ya-yu Tsai and Xiaotao Qu and Susan J Ramus and Rod Karevan and Janet Myungjin Lee and Nathan V. Lee and Melissa C. Larson and Katja K. H. Aben and Hoda Anton-Culver and Natalia N. Antonenkova and Antonis C. Antoniou and Sebastian M. Armasu and François Bacot and Laura Baglietto and Elisa V. Bandera and Jill S. Barnholtz-Sloan and Matthias W. Beckmann and Michael J. Birrer and Greg C Bloom and Natalia Valerijevna Bogdanova and Louise A Brinton and Angela R Brooks-Wilson and Robert Brown and Ralf Butzow and Qiuyin Cai and Ian G. Campbell and Jenny Chang-Claude and Stephen J. Chanock and Georgia Chenevix-Trench and Jin Quan Cheng and M Sertaç Çiçek and Gerhard A. Coetzee and Linda Sue Cook and Fergus J. Couch and Daniel W Cramer and Julie M Cunningham and Agnieszka Dansonka-Mieszkowska and Evelyn Despierre and Jennifer A. Doherty and Thilo D{\"o}rk and Andreas du Bois and Matthias D{\"u}rst and Douglas F. Easton and Diana M Eccles and Robert Edwards and Arif B. Ekici and Peter A. Fasching and David A. Fenstermacher and James M Flanagan and Montserrat Garc{\'i}a-Closas and Aleksandra Gentry-Maharaj and Graham G. Giles and Rosalind M Glasspool and Jesus Gonzalez-Bosquet and Marc T. Goodman and MartinE. Gore and Bohdan G{\'o}rski and Jacek Gronwald and P. F. L. Hall and Mari Kylles{\o} Halle and Philipp Harter and Florian Heitz and Peter Hillemanns and Maureen Elizabeth Hoatlin and Claus Kim H{\o}gdall and Estrid H{\o}gdall and Satoyo Hosono and Anna Jakubowska and Allan Jensen and Heather S L Jim and Kimberly R. Kalli and Beth Y. Karlan and Stanley B. Kaye and Linda E. Kelemen and Lambertus A Kiemeney and Fumitaka Kikkawa and Gottfried E. Konecny and Camilla Krakstad and Susanne K Kjaer and Jolanta Kupryjańczyk and Diether Lambrechts and Sandrina Lambrechts and Johnathan Mark Lancaster and Nhu Da Le and Arto Leminen and Douglas A. Levine and Dong Liang and Boon Kiong Lim and Jie Lin and Jolanta Lissowska and Karen H. Lu and Jan Lubiński and Galina Lurie and Leon Fag Massuger and Keitaro Matsuo and Valerie A McGuire and John R McLaughlin and Usha Menon and Francesmary Modugno and Kirsten B Moysich and Toru Nakanishi and Steven A Narod and Lotte Nedergaard and Roberta B. Ness and Heli Nevanlinna and Stefan Nickels and Houtan Noushmehr and Kunle Odunsi and Sara H. Olson and Irene Orlow and James Paul and Celeste Leigh Pearce and Tanja Pejovi{\'c} and L M Pelttari and Malcolm C. Pike and Elizabeth M Poole and Paola Raska and Stefan Peter Renner and Harvey A. Risch and Lorna Rodr{\'i}guez-Rodr{\'i}guez and Mary Anne Rossing and Anja Rudolph and I B Runnebaum and Iwona Krystyna Rzepecka and Helga Birgitte Salvesen and Ira Schwaab and Gianluca Severi and Vijayalakshmi Shridhar and Xiao-Ou Shu and Yurii B Shvetsov and Weiva Sieh and Honglin Song and Melissa C. Southey and Beata Śpiewankiewicz and Daniel O. Stram and Rebecca Sutphen and Soo Hwang Teo and Kathryn L. Terry and Daniel C. Tessier and Pamela J. Thompson and Shelley S Tworoger and Anne M van Altena and Ignace Vergote and Robert A Vierkant and Daniel D Vincent and Allison F. Vitonis and Shan Wang-gohrke and Rachel T. Palmieri Weber and Nicolas Wentzensen and Alice S. Whittemore and Elisabeth Wik and Lynne Ross Wilkens and Boris J.N. Winterhoff and Yin Ling Woo and Anna H Wu and Yong Bing Xiang and Hannah Yang and Wei Zheng and Argyrios Ziogas and Famida Zulkifli and Catherine M. Phelan and Edwin S. Iversen and Joellen Martha Schildkraut and Andrew Berchuck and Brooke L. Fridley and Ellen L. Goode and Paul D P Pharoah and Alvaro N. A. Monteiro and Thomas A. Sellers and Simon A. Gayther},
  booktitle={Nature communications},
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent functional targets that influence EOC susceptibility. Here, we evaluate the association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and EOC risk in 18,174 EOC cases and 26,134… CONTINUE READING
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