Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).

@article{Nepom2001IdentificationAM,
  title={Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65).},
  author={Gerald T Nepom and John D. Lippolis and Forest M. White and Susan A. Masewicz and Jarrod A. Marto and Andrew Herman and Chance John Luckey and Ben A Falk and Jeffrey Shabanowitz and Donald F. Hunt and Victor H Engelhard and Barbara S. Nepom},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 4},
  pages={1763-8}
}
T cell recognition of autoantigens is critical to progressive immune-mediated destruction of islet cells, which leads to autoimmune diabetes. We identified a naturally presented autoantigen from the human islet antigen glutamic acid decarboxylase, 65-kDa isoform (GAD65), by using a combination of chromatography and mass spectrometry of peptides bound by the type I diabetes (insulin-dependent diabetes mellitus, IDDM)-associated HLA-DR4 molecule. Peptides encompassing this epitope-stimulated… CONTINUE READING
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Prediction, Prevention and Genetic Counseling in IDDM

  • V. Mehta, J. P. Palmer
  • 1996

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