Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry.

  title={Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry.},
  author={S. Castiglioni and E. Zuccato and E. Crisci and C. Chiabrando and R. Fanelli and R. Bagnati},
  journal={Analytical chemistry},
  volume={78 24},
Residues of illicit drugs and their metabolites that are excreted by humans may flow into and through wastewater treatment plants. The aim of this study was to develop a method for the determination of cocaine, amphetamines, morphine, cannabinoids, methadone, and some of their metabolites in wastewater. Composite 24-h samples from urban treatment plants were enriched with deuterated internal standards before solid-phase extraction. High-pressure liquid chromatography tandem mass spectrometry… Expand
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Simultaneous detection of drugs of abuse in waste water using gas chromatography-mass spectrometry
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Drugs of abuse and their metabolites in waste and surface waters by liquid chromatography-tandem mass spectrometry.
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A modified version of this method that incorporates solid-phase extraction to further enhance sensitivity is presented and is sufficiently sensitive to directly quantify 18 analytes in wastewater at concentrations less than 50 ng/L. Expand
Determination of illicit drugs in the water cycle by LC-Orbitrap MS.
The societal interest in the use and abuse of illicit drugs has spurred researchers to monitor their discharges from households and municipal wastewater treatment plants and to investigate theirExpand
Determination of drugs of abuse in water by solid-phase extraction, derivatisation and gas chromatography-ion trap-tandem mass spectrometry.
Analysis of a limited number of waste and surface water samples confirmed the presence of several illicit drugs in the aquatic environment, with the highest levels and frequency corresponding to benzoylecgonine, the main metabolite of cocaine. Expand