Identification and measurement of calcitonin precursors in serum of patients with malignant diseases.

@article{Ghillani1989IdentificationAM,
  title={Identification and measurement of calcitonin precursors in serum of patients with malignant diseases.},
  author={Pascale Ghillani and P Mott{\'e} and Fr{\'e}d{\'e}ric Troalen and Annick Jullienne and Paule Gardet and Thierry Le Chevalier and Philippe Rougier and Martin Schlumberger and Claude Prof Bohuon and Dominique Bellet},
  journal={Cancer research},
  year={1989},
  volume={49 23},
  pages={
          6845-51
        }
}
Previous studies have suggested that molecular species larger than the mature calcitonin (CT) are produced by tumors of different origin. In order to study these species, we developed a monoclonal immunoradiometric assay for calcitonin precursors (CT-pr). This assay was based on both monoclonal antibody KC01 directed to the 1-11 region of katacalcin and monoclonal antibody CT08 directed to the 11-17 portion of CT. The sensitivity of this monoclonal immunoradiometric assay for CT-pr was less… CONTINUE READING
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