Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi, in Plasmodium falciparum.

@article{Wye1996IdentificationAL,
  title={Identification and localization of rab6, separation of rab6 from ERD2 and implications for an 'unstacked' Golgi, in Plasmodium falciparum.},
  author={J E Van Wye and Nafisa Ghori and Paul Webster and R R Mitschler and Heidi G. Elmendorf and Kasturi Haldar},
  journal={Molecular and biochemical parasitology},
  year={1996},
  volume={83 1},
  pages={107-20}
}
The rab6 gene product in mammalian cells and yeast is localized to and regulates protein transport in the medial and trans Golgi cisternae, as well as the trans Golgi network. We have identified a homologue in the malaria parasite Plasmodium falciparum which displays a rab-like sequence that is 62.4% identical to mammalian rab6. In addition the parasite gene (Pfrab6 gene) contains an N-terminal hydrophobic domain, unique to P. falciparum. Antibodies developed to Pfrab6 localize protein in 4-7… CONTINUE READING