Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products.

@article{Tsao2001IdentificationAL,
  title={Identification and localization of five CYP2Cs in murine extrahepatic tissues and their metabolism of arachidonic acid to regio- and stereoselective products.},
  author={C. C. Tsao and Sherry J. Coulter and A Chien and Guanzheng Luo and Natasha P Clayton and Robert R. Maronpot and Joyce A. Goldstein and Darryl C. Zeldin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2001},
  volume={299 1},
  pages={39-47}
}
The CYP2C subfamily has been extensively studied in humans with respect to the metabolism of clinically important drugs, and polymorphisms have been identified in these enzymes. In the present study, a murine model was used to determine the possible physiological functions and extrahepatic distribution of CYP2Cs. Using the reverse transcription-polymerase chain reaction (RT-PCR), Western blotting, and immununohistochemistry, this report demonstrates that the mouse CYP2Cs are extensively… CONTINUE READING
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