Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.

@article{Tu2001IdentificationAK,
  title={Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.},
  author={Yizeng Tu and Dennis F. Kucik and C Wu},
  journal={FEBS letters},
  year={2001},
  volume={491 3},
  pages={193-9}
}
Nck-2 is a newly identified adapter protein comprising three N-terminal SH3 domains and one C-terminal SH2 domain. We have identified in a yeast two-hybrid screen DOCK180, a signaling protein implicated in the regulation of membrane ruffling and migration, as a binding protein for Nck-2. Surface plasmon resonance analyses reveal that the second and the… CONTINUE READING