Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression.

@article{Fujimoto2002IdentificationAI,
  title={Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression.},
  author={Koji Fujimoto and Robert Daniel Beauchamp and Robert H. Whitehead},
  journal={Gastroenterology},
  year={2002},
  volume={123 6},
  pages={1941-8}
}
BACKGROUND & AIMS The surface epithelium of the colon is being replaced constantly with cells derived from the stem cells of the crypt. Although the location of the stem cells is known, there are no markers for these cells. This study tested the hypothesis that colonic stem cells might be isolated and cultured on the basis of specific integrin expression patterns in normal human colonic epithelium. METHODS Integrin expression in normal human colonic mucosa was determined by using indirect… CONTINUE READING

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