Identification and initial characterisation of a Plasmodium falciparum Cox17 copper metallochaperone.

@article{Choveaux2015IdentificationAI,
  title={Identification and initial characterisation of a Plasmodium falciparum Cox17 copper metallochaperone.},
  author={David L. Choveaux and Robert Gerd Erich Krause and Jude M Przyborski and J P Dean Goldring},
  journal={Experimental parasitology},
  year={2015},
  volume={148},
  pages={
          30-9
        }
}
Copper is an essential micronutrient for all living organisms as an important catalytic co-factor for key enzymes. In higher eukaryotes intracellular copper is distributed by copper metallochaperones. Copper chelators such as neocuproine and tetrathiomolybdate inhibit Plasmodium falciparum erythrocytic development, indicating a requirement for copper by the parasite. A screen of the P. falciparum genome database identified eight potential copper-requiring protein orthologs, including four… CONTINUE READING
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