Identification and in vivo Characterization of a Potential TAAR1 Antagonist

@inproceedings{Lam2017IdentificationAI,
  title={Identification and in vivo Characterization of a Potential TAAR1 Antagonist},
  author={Vincent Lam},
  year={2017}
}
TAAR1 is a G-protein coupled receptor expressed in monoaminergic regions in the brain and represents a potential novel therapeutic target for the treatment of neurological disorders. While success has been made with discovering novel selective agonists for TAAR1, only one TAAR1 antagonist has been described thus far. We used an in silico screen on a TAAR1 homology model and identified several novel agonists and potential antagonists for TAAR1. One of the identified antagonists (compound 22) was… CONTINUE READING

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