Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH.

@article{Gerasimova2010IdentificationAI,
  title={Identification and in vitro characterization of follicle stimulating hormone (FSH) receptor variants associated with abnormal ovarian response to FSH.},
  author={Tsilya Gerasimova and Maria N Thanasoula and Dimitrios Zattas and Emre Seli and Denny Sakkas and Maria D. Lalioti},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 2},
  pages={529-36}
}
CONTEXT FSH mediates cyclic follicle growth and development and is widely used for controlled ovarian stimulation in women undergoing infertility treatment. The ovarian response of women to FSH is variable, ranging from poor response to ovarian hyperstimulation. OBJECTIVE We investigated whether genetic alterations of the FSH receptor (FSHR) contribute to this variability. DESIGN AND PATIENTS Our approach was to study women undergoing treatment with in vitro fertilization falling into the… CONTINUE READING