Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4.

@article{Stadler1992IdentificationAG,
  title={Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4.},
  author={H. S. Stadler and Benzy J Padanilam and Kenneth H. Buetow and Jeffrey C Murray and Michael Solursh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 23},
  pages={11579-83}
}
A human craniofacial cDNA library was screened with a degenerate oligonucleotide probe based on the conserved third helix of homeobox genes. From this screening, we identified a homeobox gene, H6, which shared only 57-65% amino acid identity to previously reported homeodomains. H6 was physically mapped to the 4p16.1 region by using somatic cell hybrids containing specific deletions of human chromosome 4. Linkage data from a single-stranded conformational polymorphism derived from the 3… CONTINUE READING