Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.

@article{Snir2011IdentificationAF,
  title={Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.},
  author={Omri Snir and Mary Rieck and John A. Gebe and Betty B. Yue and Crystal A. Rawlings and Gerald T Nepom and Vivianne Malmstr{\"o}m and Jane H Buckner},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 10},
  pages={2873-83}
}
OBJECTIVE Antibodies toward the citrullinated form of the synovial antigen vimentin are specific for rheumatoid arthritis (RA) and are associated with HLA-DRB1*0401. This suggests that T cells specific for peptides derived from citrullinated vimentin presented in the context of HLA-DRB1*0401 may contribute to the etiopathogenesis of RA. The aim of this study was to identify immunodominant epitopes from citrullinated vimentin presented by HLA-DRB1*0401 and to characterize the resulting T cell… CONTINUE READING

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