Identification and functional characterization of nonmammalian Toll-like receptor 20

  title={Identification and functional characterization of nonmammalian Toll-like receptor 20},
  author={Danilo Pietretti and Marleen H Scheer and Inge R. Fink and Nico Taverne and Huub F J Savelkoul and Herman P. Spaink and Maria Forlenza and Geert Frits Wiegertjes},
Like other vertebrate Toll-like receptors (TLRs), the TLRs of teleost fish can be subdivided into six major families, each of which recognize a general class of molecular patterns. However, there also are a number of Tlrs with unknown function, the presence of which seems unique to the bony fish, among which is Tlr20. We identified full-length complementary DNA (cDNA) sequences for tlr20 of zebrafish and common carp, two closely related fish species. Zebrafish have six copies of tlr20, whereas… CONTINUE READING
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