Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.

@article{Krger2004IdentificationAF,
  title={Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis.},
  author={Thilo Kr{\"u}ger and Dirk Benke and Frank Eitner and Andreas Lang and Monika Wirtz and Emma E Hamilton-Williams and Daniel Engel and Bernd Giese and G M{\"u}ller-newen and Juergen Floege and Christian Kurts},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 3},
  pages={613-21}
}
The kidney tubulointerstitium contains numerous bone marrow-derived antigen-presenting cells, which are often referred to as resident tissue macrophages, although several previous studies had demonstrated characteristics of dendritic cells (DC). In this study, we describe a subset of tubulointerstitial cells expressing the DC marker CD11c. A protocol was established to isolate these cells for in vitro analysis. Renal CD11c(+) cells resembled splenic DC, but not peritoneal macrophages, in… CONTINUE READING
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: Specialized and regulated antigen processing machines

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