Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms.

@article{Gosenca2014IdentificationAF,
  title={Identification and functional characterization of imatinib-sensitive DTD1-PDGFRB and CCDC88C-PDGFRB fusion genes in eosinophilia-associated myeloid/lymphoid neoplasms.},
  author={Darko Gosenca and Beate Kellert and Georgia Metzgeroth and Claudia Haferlach and Alice Fabarius and Juliana Schwaab and Michael Kneba and Christof Scheid and Karin Toepelt and Philipp Erben and Torsten Haferlach and Nicholas C P Cross and Wolf-Karsten Hofmann and Wolfgang Seifarth and Andreas Reiter},
  journal={Genes, chromosomes & cancer},
  year={2014},
  volume={53 5},
  pages={411-21}
}
Eosinophilia-associated myeloid neoplasms with rearrangement of chromosome bands 5q31-33 are frequently associated with PDGFRB fusion genes, which are exquisitely sensitive to treatment with imatinib. In search for novel fusion partners of PDGFRB, we analyzed three cases with translocation t(5;20)(q33;p11), t(5;14)(q33;q32), and t(5;17;14)(q33;q11;q32) by 5′-rapid amplification of cDNA ends polymerase chain reaction (5′-RACE-PCR) and DNA-based long-distance inverse PCR (LDI-PCR) with primers… CONTINUE READING