Identification and functional characterization of eight CYP3A4 protein variants.

@article{Eiselt2001IdentificationAF,
  title={Identification and functional characterization of eight CYP3A4 protein variants.},
  author={Regina Eiselt and T L Domanski and Arne Zibat and Ralph M{\"u}ller and E Presecan-Siedel and Elisabeth Hustert and Ulrich M. Zanger and J{\"u}rgen Brockmoller and Hans Peter Klenk and Urs A. Meyer and Kishore K. Khan and Y A He and James R. Halpert and Leszek Wojnowski},
  journal={Pharmacogenetics},
  year={2001},
  volume={11 5},
  pages={447-58}
}
The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but the underlying genetic factors remain largely unknown. A study of 213 Middle and Western European DNA samples resulted in the identification of 18 new CYP3A4 variants, including eight protein variants. A total of 7.5% of the population studied was found to be heterozygous for one of these variants. In a bacterial heterologous expression system, two mutants, R130Q and… CONTINUE READING

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