Identification and functional characterization of eight CYP3A4 protein variants.

@article{Eiselt2001IdentificationAF,
  title={Identification and functional characterization of eight CYP3A4 protein variants.},
  author={R. Eiselt and T. Domanski and A. Zibat and R. Mueller and E. Presecan-Siedel and E. Hustert and U. M. Zanger and J. Brockmoller and H. Klenk and U. Meyer and K. K. Khan and Y. He and J. Halpert and L. Wojnowski},
  journal={Pharmacogenetics},
  year={2001},
  volume={11 5},
  pages={
          447-58
        }
}
The genetic component of the inter-individual variability in CYP3A4 activity has been estimated to be between 60% and 90%, but the underlying genetic factors remain largely unknown. A study of 213 Middle and Western European DNA samples resulted in the identification of 18 new CYP3A4 variants, including eight protein variants. A total of 7.5% of the population studied was found to be heterozygous for one of these variants. In a bacterial heterologous expression system, two mutants, R130Q and… Expand
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