Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium.

@article{Iqbal2005IdentificationAF,
  title={Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium.},
  author={Muhammad Atif Iqbal and Victoria Jane Philbin and G. S. K. Withanage and Paul Wigley and Richard K. Beal and Marianne J Goodchild and Paul Barrow and Ian McConnell and Duncan J Maskell and John Young and Nat Bumstead and Yvonne Boyd and Adrian Lloyd Smith},
  journal={Infection and immunity},
  year={2005},
  volume={73 4},
  pages={2344-50}
}
Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In chickens, the differential biology of Salmonella serovars (systemic versus gut-restricted localization) correlates with the presence or absence of flagella, a known TLR5 agonist. Chicken TLR5 (chTLR5) exhibits conserved sequence and structural similarity with mammalian TLR5 and is expressed in… CONTINUE READING