Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein.

@article{Angulo1991IdentificationAE,
  title={Identification and expression of the cDNA of KIN17, a zinc-finger gene located on mouse chromosome 2, encoding a new DNA-binding protein.},
  author={Jaime F. Angulo and Evelyne Rouer and Alexander Mazin and M. G. Matt{\'e}i and Alain Tissier and Philippe Horellou and Richard B{\'e}narous and Raymond Devoret},
  journal={Nucleic acids research},
  year={1991},
  volume={19 19},
  pages={5117-23}
}
We report the cloning of KIN17 cDNA, 1414 bp long with an ORF of 391 residues showing a zinc finger and nuclear localization signals. By recloning the cDNA into an appropriate vector, we produced kin17 protein in E. coli, purified it partially and shown that kin17 protein binds to double-stranded DNA. The KIN17 gene was localized by cytogenetic mapping in mouse chromosome 2, band A. Genomic sequences homologous to KIN17 cDNA were detected also in rat and human DNAs. KIN17 mRNA is highly… CONTINUE READING
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