Identification and evaluation of the role of endogenous tyrosine kinases in azoxymethane induction of proliferative processes in the colonic mucosa of rats.

@article{Relan1995IdentificationAE,
  title={Identification and evaluation of the role of endogenous tyrosine kinases in azoxymethane induction of proliferative processes in the colonic mucosa of rats.},
  author={N K Relan and Ahmad Saeed and K Ponduri and Suzanne E. G. Fligiel and Sushanta Dutta and Adhip P. N. Majumdar},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1244 2-3},
  pages={368-76}
}
Although tyrosine kinases (Tyr-k) are known to play a role in regulating proliferation of normal, preneoplastic and neoplastic cells, little is known about the identity of different species of Tyr-k involved in this process. Utilizing a non-denaturing polyacrylamide gel electrophoresis system, in which the separated proteins from tissue extracts are assayed directly for Tyr-k, we attempted to identify the species of Tyr-k that may be involved in azoxymethane (AOM) induction of colonic mucosal… CONTINUE READING
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