Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit.

@article{Rosskopf2002IdentificationAE,
  title={Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit.},
  author={Dieter Rosskopf and Iris Manthey and Winfried Siffert},
  journal={Pharmacogenetics},
  year={2002},
  volume={12 3},
  pages={209-20}
}
The 825T-allele of the gene GNB3 encoding the G protein beta3 subunit is associated with hypertension and obesity, and identifies individuals highly responsive to diuretic therapy. Gbeta3s, a Gbeta3 protein variant generated by alternative splicing in carriers of the 825T-allele, is linked to increased signal transduction and is a potential cause for the observed pathophysiology. Here, we searched the entire GNB3 gene for additional polymorphisms and analysed their prevalence in Caucasian… CONTINUE READING

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