Identification and dynamic modeling of biomarkers for bacterial uptake and effect of sulfonamide antimicrobials.

@article{Richter2013IdentificationAD,
  title={Identification and dynamic modeling of biomarkers for bacterial uptake and effect of sulfonamide antimicrobials.},
  author={Merle K Richter and A. Focks and B. Siegfried and D. Rentsch and M. Krauss and R. Schwarzenbach and J. Hollender},
  journal={Environmental pollution},
  year={2013},
  volume={172},
  pages={
          208-15
        }
}
The effects of sulfathiazole (STA) on Escherichia coli with glucose as a growth substrate was investigated to elucidate the effect-based reaction of sulfonamides in bacteria and to identify biomarkers for bacterial uptake and effect. The predominant metabolite was identified as pterine-sulfathiazole by LC-high resolution mass spectrometry. The formation of pterine-sulfathiazole per cell was constant and independent of the extracellular STA concentrations, as they exceeded the modeled half… Expand
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