Identification and distribution of the costimulatory receptor CD28 in the mouse.

@article{Gross1992IdentificationAD,
  title={Identification and distribution of the costimulatory receptor CD28 in the mouse.},
  author={Jane A. Gross and E Callas and James P Allison},
  journal={Journal of immunology},
  year={1992},
  volume={149 2},
  pages={380-8}
}
T cell activation requires Ag-specific stimulation mediated by the TCR as well as an additional stimulus provided by Ag presenting cells. On human T cells, it has been shown that antibodies to the Ag CD28 can provide a potent amplification signal for cytokine production and proliferation. Here we describe the production of a mAb to the murine homologue of CD28, and the use of this antibody to examine the function and distribution of CD28 in the mouse. Anti-murine CD28 synergizes with TCR… CONTINUE READING
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