Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

@article{Kilpatrick1987IdentificationAD,
  title={Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding},
  author={Gavin Kilpatrick and Brian J. Jones and Michael Brian Tyers},
  journal={Nature},
  year={1987},
  volume={330},
  pages={746-748}
}
Functional serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into three subtypes: 5-HT1,-like, 5-HT2 and 5-HT3, (ref. 1). Brain binding sites have been identified for both the 5-HT1, and 5-HT2 subtypes. Receptors of the 5-HT3 type have been characterized on isolated peripheral tissue models such as the rat vagus nerve2, guinea-pig ileum3 and isolated rabbit heart4. Using these models, selective 5-HT3 receptor antagonists such as MDL 72222 (ref. 5), ICS 205-930 (ref. 6), GR38032F… Expand
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